QIAGEN OmicSoft and Biomedical Knowledge Base

Indication expansion and drug repurposing using QIAGEN OmicSoft and Ingenuity Pathway Analysis

465 views
August 16, 2023
Research and development for new drugs and disease treatments can be lengthy and costly. Indication expansion can help broaden the impact of a new drug that has already been through the arduous R&D process for a disease or cancer. Drug repurposing can take this concept and expand on it by looking for other diseases with similar drug target biology. The logic is if they share similar target biology, they may benefit from the same treatment.

During this training, we'll cover skills such as:
• Querying QIAGEN OmicSoft Lands data from sources like TCGA or ICGC and exploring the incidence of a cancer-driving somatic mutation that is targeted by a treatment
• Creating a cohort of patients within OmicSoft with a disease-causing mutation and wild type for the gene of interest
• Generating survival curves for each mutant and wild type group for various indications in the relevant OmicSoft Land
• Using QIAGEN Ingenuity Pathway Analysis (IPA) to generate a mechanism of action network for the drug's target
• Exploring various network overlay features to enable in silico testing and combination drug partner investigation
• Searching for publicly available datasets relevant to your chosen indication
• Comparing the expression profile from our disease state with other publicly available analyses to find other indications or diseases that share similar biology

Related videos

QIAGEN OmicSoft and Biomedical Knowledge Base

Knowledge graphs and more: Analytics-driven drug discovery using advanced biomedical...

1,984 views July 19, 2022

High-quality biomedical relationships knowledge is the cornerstone of modern...

QIAGEN OmicSoft and Biomedical Knowledge Base

Supercharge your AI in drug discovery with high-quality biomedical data

647 views October 11, 2023

If you’re working in pharma or biotech, you likely rely on artificial...

QIAGEN OmicSoft and Biomedical Knowledge Base

Unlocking the power of API-based 'omics queries

589 views June 12, 2023

If you're a data scientist or bioinformatician working in biopharma, here's...

QIAGEN OmicSoft and Biomedical Knowledge Base

Integrating deeply curated omics data with APIs for biomarkers and drug-target investigation

476 views September 19, 2023

If you’re a data scientist or bioinformatician working in biopharma and need...