QCI Interpret for Oncology

Mitigating Variability in Somatic Variant Interpretation: An Expert Panel

January 16, 2023
Next-generation sequencing (NGS) oncology panels are becoming integral in hospital and academic settings to guide patient treatment and enrollment in clinical trials. But as NGS is increasingly used in precision oncology and an unprecedented amount of genomic information is uncovered, there is an industry-wide issue of standardization: a high degree of variability in variant interpretation currently exists across laboratories.

Inconsistencies in variant interpretation among laboratories can create confusion for clinicians and their patients, leaving them unable to confidently use genetic information to manage healthcare decisions. In this live panel discussion, experts in NGS testing and clinical informatics explore the issues surrounding the standardization of variant interpretation and consider how interpretation guidelines and clinical decision support (CDS) software can help to mitigate variability between laboratories.

Topics of discussion include:

  • Findings of a peer-reviewed study comparing the accuracy and consistency of variant assessments from commercial CDS software to the internal variant interpretation methods of eight laboratories.
  • Causes of inter-laboratory inconsistency in variant interpretation and how to mitigate variability.
  • The benefits of having an up-to-date, high-quality knowledge base to produce consistent, evidence-based clinical classifications.

Related videos

QCI Interpret for Oncology

How to scale-up comprehensive genomic profiling and deliver confident variant interpretations...

46 views November 10, 2023

As gene panels increase in size, comprehensive genomic profiling and variant...

Real-World Insights

Real-World Applications of Clinical Metagenomic Sequencing in Cancer and Infectious Disease...

88 views October 31, 2023

Clinical metagenomic next-generation sequencing (mNGS), the comprehensive...

QCI Interpret for Oncology

Scale your comprehensive genomic profiling workflow with superior automated variant interpretation

121 views June 28, 2023

Automating and scaling a comprehensive genomic profiling workflow can be a...

QCI Interpret for Oncology

Comprehensive Molecular Tumor Analysis with Alacris Theranostics

197 views March 09, 2023

Precision oncology approaches have made great strides harnessing individual...