This session traces the evolution of comprehensive cancer genome profiling (CGP) and liquid biopsy techniques in South East Asia, discussing the initial hurdles and ultimate triumphs. It details how interventions like international collaborations, technological enhancements, and policy support have enabled these advanced diagnostic tools' successful adoption. Highlighting the critical role of liquid biopsy in early cancer detection and monitoring treatment efficacy, the study underscores the importance of continued genomics research and investment for improved cancer care globally. It illustrates that, despite significant challenges, integrating advanced genomic profiling into oncology practice is attainable and transformative.