QCI Interpret for Oncology

Expert panel: Mitigating variability in somatic variant interpretation

June 06, 2024
Next-generation sequencing (NGS) oncology panels are becoming integral in hospital and academic settings to guide patient treatment and enrollment in clinical trials. But as NGS is increasingly used in precision oncology and an unprecedented amount of genomic information is uncovered, there is an industry-wide issue of standardization: a high degree of variability in variant interpretation currently exists across laboratories.

Inconsistencies in variant interpretation among laboratories can create confusion for clinicians and their patients, leaving them unable to confidently use genetic information to manage healthcare decisions. In this previously aired live panel discussion, experts in NGS testing and clinical informatics explore the issues surrounding the standardization of variant interpretation and consider how interpretation guidelines and clinical decision support (CDS) software can help to mitigate variability between laboratories.

Topics of discussion include:

Findings of a peer-reviewed study comparing the accuracy and consistency of variant assessments from commercial CDS software to the internal variant interpretation methods of eight laboratories.
Causes of inter-laboratory inconsistency in variant interpretation and how to mitigate variability.
The benefits of having an up-to-date, high-quality knowledge base to produce consistent, evidence-based clinical classifications.

Related videos

QCI Interpret for Oncology

QCI Interpret One: Oncology variant interpretation just got more precise

1,018 views June 12, 2020

Competing to offer a comprehensive genomic profiling service for solid or...

QCI Interpret for Oncology

Precision medicine for any cancer assay on any platform

1,013 views May 29, 2019

For NGS cancer testing, keeping pace with new discoveries is a serious...

QCI Interpret for Oncology

Managing multiple biomarker therapeutic development

403 views September 12, 2019

For the past two decades, the paradigm in the field has been “one biomarker,...

QCI Interpret for Oncology

FASTQ to final report: Ultra-fast workflow for CGP

371 views July 21, 2022

As our molecular knowledge of cancer continually evolves, a new era in cancer...