QIAGEN IPA

Cross-species comparison and validation for drug discovery and biomarker research using QIAGEN Ingenuity Pathway Analysis (IPA)

270 views
September 27, 2023
Some human studies may be unfeasible or unethical, making cross-species research critical for drug discovery and biomarker validation. Cross-species research is a crucial method to collect data to examine potential toxicity for a candidate drug, determine the efficacious doses that may be suitable for humans, identify potential biomarkers for a disease of interest or a therapeutic response and understand the mechanisms of disease or treatment. While animal models and humans have similar anatomy and physiology, the subtle differences among organisms in the animal kingdom need to be considered and data collected must be interpreted using a meaningful method.

Using QIAGEN IPA, you can perform comparative analyses across various animal models, even combining different time points, treatments, tissues and cell types with data generated from a wide variety of ‘omics technologies (RNA-seq, scRNA-seq, proteomics, metabolomics, etc.). In this training, you will learn how to:
1. Generate activity heatmaps and expression charts comparing different pathways and regulatory networks across different species
2. Use Activity Plot, Pattern Search and Analysis Match to compare your own data against thousands of public data pre-curated and pre-analyzed representing an array of disease states, conditions and other biological conditions
3. Create expression and correlation plots using pre-curated and pre-analyzed public data to validate and confirm findings derived from a comparison analysis

Related videos

QIAGEN IPA

Exploring COVID-19 implicated genes in QIAGEN IPA and OmicSoft Land Explorer

267,437 views April 01, 2020

Interested in learning more? Click here

QIAGEN IPA

Analyze, compare and contextualize your biological data with QIAGEN IPA

95,020 views June 07, 2023

Discover why QIAGEN Ingenuity Pathway Analysis (IPA) is more than just...

QIAGEN IPA

IPA Webinar: Part 1: Introduction to Ingenuity Pathway Analysis

40,454 views November 12, 2019

Learn how to quickly and easily identify significant pathways, discover...

QIAGEN IPA

IPA Webinar: Part 2: Formatting and Uploading Your Dataset into IPA

20,829 views November 12, 2019

IPA has broadly been adopted by the life science research community and is...