Discovery and Research
Using QIAGEN Digital Insights to determine how LY6E impairs coronavirus fusion and confers immune control
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Zoonotic coronaviruses (CoVs) are significant threats to global health, as exemplified by the recent emergence of SARS-CoV-2. Host immune responses to CoV are complex and regulated in part through antiviral interferons. However, the interferon-stimulated gene products that inhibit CoV are not well characterized. In this webinar, we explain the findings of our recent study in which we identified LY6E as a broad coronavirus restriction factor. Our findings advance our understanding of immune-mediated control of CoV in vitro and in vivo and could help in the development of new strategies to combat infection by emerging CoV.
In this webinar, we will discuss:
In this webinar, we will discuss:
- How interferon-inducible lymphocyte antigen 6 complex, locus E (LY6E) restricts cellular infection by multiple CoVs, including SARS-CoV, SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV)
- Mechanistic studies which reveal that LY6E inhibits CoV entry into cells by interfering with spike protein-mediated membrane fusion
- How mice lacking Ly6e in hematopoietic cells were highly susceptible to murine CoV infection
- LY6E as a critical antiviral immune effector that controls CoV infection and pathogenesis
- The results of our transcriptomic analysis of coronavirus infected mice
- How QIAGEN Digital Insights supported our transcriptomic analyses and enabled us to gain deeper insights into gene expression during CoV infection
Interested in learning more?
Speakers:
Dr. Stephanie Pfaender, Ph.D., Ruhr University Bochum, Germany, Department for Molecular and Medical Virology
Dr. Daniel Todt, Ph.D., Ruhr University Bochum, Germany, Department for Molecular and Medical Virology
Dr. Jean-Noel Billaud, Ph.D., Senior Principal Scientist, QIAGEN IPA
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