Discovery and Research

Using QIAGEN Digital Insights to determine how LY6E impairs coronavirus fusion and confers immune control

338 views
May 06, 2020
Zoonotic coronaviruses (CoVs) are significant threats to global health, as exemplified by the recent emergence of SARS-CoV-2. Host immune responses to CoV are complex and regulated in part through antiviral interferons. However, the interferon-stimulated gene products that inhibit CoV are not well characterized. In this webinar, we explain the findings of our recent study in which we identified LY6E as a broad coronavirus restriction factor. Our findings advance our understanding of immune-mediated control of CoV in vitro and in vivo and could help in the development of new strategies to combat infection by emerging CoV.

In this webinar, we will discuss:
  • How interferon-inducible lymphocyte antigen 6 complex, locus E (LY6E) restricts cellular infection by multiple CoVs, including SARS-CoV, SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV)
  • Mechanistic studies which reveal that LY6E inhibits CoV entry into cells by interfering with spike protein-mediated membrane fusion
  • How mice lacking Ly6e in hematopoietic cells were highly susceptible to murine CoV infection
  • LY6E as a critical antiviral immune effector that controls CoV infection and pathogenesis
  • The results of our transcriptomic analysis of coronavirus infected mice
  • How QIAGEN Digital Insights supported our transcriptomic analyses and enabled us to gain deeper insights into gene expression during CoV infection

Interested in learning more?

QIAGEN IPA 

QIAGEN CLC Genomics

Speakers:

Dr. Stephanie Pfaender, Ph.D., Ruhr University Bochum, Germany, Department for Molecular and Medical Virology

Dr. Daniel Todt, Ph.D., Ruhr University Bochum, Germany, Department for Molecular and Medical Virology

Dr. Jean-Noel Billaud, Ph.D., Senior Principal Scientist, QIAGEN IPA

Related videos

Discovery and Research

Multi-omic changes in the postnatal mouse heart identified by QIAGEN Ingenuity Pathway Analysis...

286 views May 18, 2020

Multi-omics experiments allow researchers to make important discoveries in...

Discovery and Research

Discovery from public oncological data using QIAGEN Omicsoft OncoLand and QIAGEN Ingenuity...

168 views June 18, 2021

In this 90-minute training, we will discuss how to discover and validate...

Discovery and Research

Discover hidden relationships in your toxicological studies with QIAGEN IPA

122 views April 23, 2020

QIAGEN Ingenuity Pathway Analysis (IPA) reveals the hidden upstream drivers...

Discovery and Research

From data to biological insight using QIAGEN CLC Single Cell Module and QIAGEN IPA: Single-cell...

198 views June 11, 2021

Organ development during gestation is a complex series of hematopoietic...