Neutrophils, known for killing microbes, can be both beneficial and harmful during a tuberculosis (TB) infection. While neutrophils kill the bacteria early on, they also contribute to chronic inflammation and lung tissue destruction. However, recent studies show that these roles are associated with different subsets of neutrophils: regulatory ones that display major histocompatibility complex (MHC)-II and the classical MHC-II- neutrophils.

In this webinar, Dr. Aude Remot from Université de Tours, France, will share how they identified functionally and transcriptionally distinct neutrophil subsets in the lungs of tuberculosis-infected mice. Afterward, her team expanded this research towards bovine TB physiopathology.

Learn how:

• Responses between inflammatory and regulatory neutrophils differ

• Regulatory neutrophils can pave the way for the discovery of new biomarkers and therapeutic interventions towards better TB management

• QIAGEN Ingenuity Pathway Analysis (IPA) was used to streamline the analysis, biological interpretation and correlation of bovine and mouse RNA-seq data

• IPA helped identify primers to target specific pathways for high-throughput qPCR

Speaker:

Aude Remot, PhD

Immunology researcher, Université de Tours ISP (Infectiology and Public Health)

Aude Remot, PhD, is an immunology researcher who has been working at the UMR1282 INRAE-Université de Tours ISP (Infectiology and Public Health) since 2015. While her research projects mainly focus on the physiopathology of bovine tuberculosis and the role of neutrophil subsets, her expertise covers innate immunity, host-microbial interactions, vaccinology and infectiology.

Before her current role, Dr. Remot obtained her PhD at the INRAE ​​VIM unit in Jouy-en-Josas, where she studied the immune lung factors responsible for neonatal sensitivity to the respiratory syncytial virus. She went on to the University of Gent in Belgium, where she completed her post-doctorate on the role of lung microbiota in the establishment of lung immunity, using an asthma model.

Dr. Remot has also been a member of the steering committee of the Neutrophil Club since 2023, which is attached to the French Society of Immunology.