Cancer remains a leading cause of death among children and adolescents worldwide. While many childhood cancers are highly curable, outcomes vary dramatically, with survival rates ranging from 80% in high-income countries to as low as 30% in lower-income regions. These disparities highlight the urgent need for more targeted research into the genetic factors influencing cancer development, early detection and timely, effective treatment.

Despite its importance, pediatric cancers receive only about 4% of global cancer research funding, leaving significant gaps in our collective understanding. Comprehensive, high-quality data is vital to closing these gaps, driving evidence-based care improvements and informing both national and global health policy.

To help these efforts, the Catalogue of Somatic Mutations in Cancer (COSMIC) v102 release focuses on pediatric cancers, showcasing a wealth of genomic data from recent targeted screens. This webinar will:

• Explore selected highlights from the new release

• Leverage deep curation of patient metadata to compare alterations in childhood vs. adult cancers

• Demonstrate how COSMIC’s focus areas of stratification, cause and effect and clinical insights enable progress in this critically under-explored area